The cover sheet of the first article with a new hypothesis on the function of the pancreas in secreting insulin is by Drs. Banting and Best, in this 1922 article (see first page below)
A reprint of an article on the first use of insulin on a human patient is in the Dr. Banting et al. original study is annotated and shown below. Look at the parts of the journal article to note the introduction, background research or literature review, a hypothesis, description of the method of the experiments, collection and analysis of the data and the conclusion, and a short list of references.
Banting, F. G., Best, C. H., Collip, J. B., Campbell, W. R., & Fletcher, A. A. (1991). Pancreatic extracts in the treatment of diabetes mellitus: preliminary report. 1922. CMAJ: Canadian Medical Association Journal, 145(10), 1281–1286.
